肥胖与代谢研究室_分子心血管重点室

Guoheng Xu received his bachelor degree (MD equivalent) of medicine in 1987 and received his master degree in Pharmacology in 1990, from Henan Medical University (China). Then he joined as a faculty at the Department of Pharmacology in the same university. In 1995, he earned his PhD degree at the Department of Pharmacology of Sun Y Medical University (Guangzhou, China). After then he became a postdoctoral fellow at Beijing University Neuroscience Institute. From 1997 to 2002, He worked as a visiting fellow at the U.S National Institute of Child Health and Human Development and then in the U.S. National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health (NIH), Maryland, USA. He returned to China at the end of 2002, and then was appointed as a professor at the Department of Physiology and Pathophysiology, Beijing University Health Science Center. He is also principle investigator at Beijing University Diabetes Center and at the Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China.

科研项目：

承担973项目，国家自然科学基金，北京市自然科学基金，新世纪优秀人才支持计划基金。

研究方向：

1. 脂肪分解的分子调控

2. 细胞内脂滴与脂滴包被蛋白的功能调控

3. 肥胖与胰岛素抵抗

甘油三酯储存在脂肪细胞内的油滴中。Perilipin等几种同源蛋白质分子覆盖在细胞内脂滴表面，参与脂滴的生成、储存、分解调控。脂滴包被蛋白Perilipin和ADRP的时序性表达与脂滴成长和脂肪细胞的分化成熟密切相关，因而在PPARγ介导的脂肪生成与脂肪细胞分化过程中起关键作用。脂肪组织甘油三酯水解释放游离脂肪酸到血液和各种组织。脂肪分解异常与血脂紊乱、肥胖、糖尿病胰岛素抵抗密切相关。我们发现Perilipin磷酸化和去磷酸化可门控性调节脂肪分解反应；激素及药物可通过Perilipin调节脂肪酸运动，进而影响胰岛素敏感性。我们研究脂滴包被蛋白及其调控甘油三酯水解的分子机制，并研究生理和病理情况下影响脂肪分解、肥胖、胰岛素敏感性、泡沫细胞形成的细胞和分子生物学调控机制。

His research interests include (1) regulationn of intracellular lipid droplet and its associating proteins, (2) regulation of lipolysis in adipocyte, and (3) obesity and insulin resistance.

Selected Publications (*as correspondent author)

1. Liping Fang, Jing Zhao, Yu Chen, Tiemin Ma, Guoheng Xu, Chaoshu Tang, Xinmin Liu, and Bin Geng. Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator. Journal of Hypertension. 2009; DOI:10.1097/HJH.0b013e328330a900

2. Chong Xu, Jinhan He, Hongfeng Jiang, Luxia Zu, Wenjie Zhai, Shenshen Pu, and Guoheng Xu*. Direct effect of glucocorticoids on lipolysis in adipocytes. Molecular Endocrinology, 2009; 23(8): 1161-1170.

3. Jörgen Borg, Cecilia Klint, Nils Wierup, Kristoffer Ström, Sara Larsson, Frank Sundler, Roberto Lupi, Piero Marchetti, Guoheng Xu, Alan Kimmel, Constantine Londos, and Cecilia Holm. Perilipin is present in islets of Langerhans and protects against lipotoxicity when overexpressed in the b-cell line INS-1. Endocrinology, 2009, 150(7): 3049-3057

4. Luxia Zu, Jinhan He, Hongfeng Jiang, Chong Xu, Shenshen Pu, and Guoheng Xu*. Bacterial Endotoxin Stimulates Adipose Lipolysis via Toll-Like Receptor 4 and Extracellular Signal-Regulated Kinase Pathway. Journal of Biological Chemistry. 2009, 284(9): 5915-26. This article was selected as “recommended” by Faculty of 1000 Biology (F1000 factor 3.0) on May 26, 2009.

5. Tingting Zhang, Jinhan He, Chong Xu, Luxia Zu, Hongfeng Jiang, Shenshen Pu, Xiaohui Guo, and Guoheng Xu*. Mechanisms of Metformin Inhibiting Lipolytic Response to Isoproterenol in Primary Rat Adipocytes. Journal of Molecular Endocrinology. 2009, 42: 57-66

6. Yin Li, Changtao Jiang, Guoheng Xu, Nanping Wang, Yi Zhu, Chaoshu Tang, and Xian Wang. Homocysteine upregulates resistin production from adipocytes in vivo and in vitro. Diabetes. 2008; 57: 817-827

7. Luxia Zu, Hongfeng Jiang, Jinhan He, Chong Xu, Shenshen Pu, Meifang Liu, and Guoheng Xu*. Salicylate Blocks Lipolytic Actions of Tumor Necrosis Factor-a in Primary Rat Adipocytes. Molecular Pharmacology. 2008, 73(1): 215-223 *责任作者。

8. Hongfeng Jiang, Jinhan He, Shenshen Pu, Chaoshu Tang, and Guoheng Xu*. Heat shock protein 70 translocates to the lipid droplet surface in adipocytes upon heat shock stress. Biochimica Biophysica Acta – Lipid, 2007, 1771(1): 66-74. *Corresponding author

9. Tingting Ren, Jinhan He, Hongfeng Jiang, Luxia Zu, Shenshen Pu, Xiaohui Guo*, and Guoheng Xu*. Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-a or isoproterenol. Journal of Molecular Endocrinology. 2006, 37(1): 175-183. *责任作者。

10. Jinhan He, Hongfeng Jiang, John T. Tansey, Chaoshu Tang, Shenshen Pu, and Guoheng Xu*. Calyculin and Okadaic Acid Promote Perilipin Phosphorylation and Increase Lipolysis in Primary Rat Adipocytes. Biochimica Biophysica Acta -Mol Cell Biol of Lipid. 2006; 1761(2): 247-255. *责任作者。

11. Xu G*, Sztalryd C, Kimmel AR, and Londos C. Degradation of perilipin is mediated through ubiquitination-proteasome pathway. Biochimica Biophysica Acta - Mol Cell Biol of Lipid. 2006; 1761(1): 83-90. *责任作者。

12. Xu G, Sztalryd C, Lu X, Dorward H, Tansey JT, Kimmel AR, and Londos C. Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway. Journal of Biological Chemistry. 2005; 280(52):42841-42847.

13. Zhang M, Wang X, Zhang D, Xu G, Dong H, Yu Y, Han J. Orphanin FQ antagonizes the inhibition of Ca(2+) currents induced by micro-opioid receptors. Journal of Molecular Neuroscience. 2005;25(1):21-27.

14. Sztalryd C, Xu G*(co-first author), Dorward H, Tansey JT, Contreras JA, Kimmel AR, and Londos C. Perilipin A is Essential for the Translocation of Hormone-sensitive Lipase during Lipolytic Activation. Journal of Cell Biology. 2003; 161(6): 1093-1103.

15. C Londos, C Sztalryd, JT Tansey, G Xu, X Lu, JW Gan, and AR Kimmel. Functional roles of perilipins and related lipid droplet-associated (PAT) proteins. Progress in Obesity Research: 9. Edited by Geraldo Medeiros-Neto, Alfredo Halpem and Claude Bouchard. 2003 John Libbey Eurotext Ltd, pp. 165-170.

16. Xu G, Rabadan-Diehl C, Nikodemova M, Wynn P, Spiess J, Aguilera G. Inhibition of corticotropin releasing hormone type-1 receptor translation by an upstream AUG triplet in the 5' untranslated region. Molecular Pharmacology. 2001; 59(3):485-492.

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