代谢与心血管疾病研究室_分子心血管重点室

朱毅：1983年毕业于西安医科大学，1986年在同校获硕士学位。1993年在瑞士洛桑大学医学院获医学博士学位。 1993-1997年先后在美国纽约医学院实验病理系和加州大学Riverside校区生物医学系做博士后。1998年-2003年在加州大学Riverside校区生物医学系任研究助理教授。 2003年底起在北京大学医学部生理学与病理生理学系任教授。多年来一直从事血管内皮激活的信号传导，脂蛋白与动脉粥样硬化形成的分子机制等方面研究，共在SCI核心期刊发表论文五十余篇。目前为1项国家科技部重大蛋白质项目首席科学家，并承担自然科学基金重点项目1项，科技部“973”基础研究项目1项。任国际心脏研究会（ISHR）中国分会秘书，《Journal of Diabetes》、《中华病理生理学杂志》《生理科学进展》等杂志的编委。

研究方向：血管内皮的信号传导与动脉粥样硬化发病机制为主的血管分子生物学、脂代谢紊乱与糖尿病。目前进行的课题包括：1) 内皮细胞中代谢性核受体的调节机制； 2) 内皮细胞膜亚结构caveolea的功能蛋白质组学；3) 花生四烯酸代谢与心血管疾病调控；4) 血流动力学在局灶性动脉粥样硬化形成中的作用机制。

Education and Employment:

B.S. in Medicine in 1983 and M.S. in 1986 from Xi’an Medical University; M.D. in 1993 from University of Lausanne. Postdoctoral training 1993-1997 at New York Medical College and University of California, Riverside; Research Assistant Professor 1998-2003 in University of California, Riverside, Division of Biomedical Sciences; Professor in Physiology since 10/2003 at Peking University Health Sciences Center.

Research Interests:

Endothelial biology and physiology, including signal transduction in vascular endothelial cells and mechanism of atherosclerosis; the relationship between dyslipidemia and type II diabetes. Currently, leading projects include 1) Regulation of metabolic nuclear receptors in vascular endothelial cell; 2) Functional proteomics of endothelial membrane microdomain caveolae; 3) Role of metabolites of arachidonic acid in cardiovascular diseases; 4) Role of homodynamic forces in the focal feature of atherosclerosis.

Representative publications:

1. Ai D, Pang W, Xie X, Xu M, Zhang YY, Chiamvimonvat N, Shyy J.Y-J. Hammock BD, Zhu Y*. (2009) A novel mechanism of Angiotensin II-induced cardiac hypertrophy – The role of soluble epoxide hydrolase. Proc Natl Acad Sci USA. 106:564-569

2. Ai D, Shyy JY-J, Zhu Y* (2009) Linking an Insect Enzyme to Hypertension: Angiotensin II - Epoxide Hydrolase Interactions. Kidney International (Invited Review) (In press).

3. Dang HX, Liu Y, Pang W, Wang NP, Shyy J. Y-J, Zhu Y* (2009) Suppression of 2,3-oxidosqualene cyclase by high-fat diet contributes to liver X receptor-a-mediated improvement of hepatic lipid profile. J. Biol Chem 284:6218-26.

4. Xie XF, Liao HL, Dang HX, Pang W, Guan YF, Wang X, Shyy JY-J, Zhu Y*, Sladek FM*. (2009) Down regulation of hepatic HNF4a gene expression during hyperinsulinemia via SREBPs. Mol Endocrinol 23:434-443.

5. Lei C, Niu XL*, Wei J, Zhu J, Zhu Y* (2009) Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy. Clinica Chimica Acta 399:102-108

6. Li X, Han Y, Pang W, Li C, Shyy J, Zhu Y* (2008) AMP-Activated Protein Kinase Promotes the Differentiation of Endothelial Progenitor Cells via eNOS-derived NO. Arterio Thromb Vasc Biol. 28:1789-95.

7. Qin X, Xue XF, Fan Y, Tian J, Guan Y, Wang X, Zhu Y*, Wang N* (2008) Inhibition of SREBP-1c-mediated Lipogenesis by PPARd in Hepatocytes via the Induction of Insulin-induced Gene-1. Hepatology. 48:432-41.

8. Zhu M, Fu Y, Wang N, Guan Y, Tang CS, Shyy J.Y-J., Zhu Y* (2008) Laminar Shear Stress Regulates Liver X Receptor in Vascular Endothelial Cells In vitro and In vivo. Arterio Thromb Vasc Biol. 28:527-533.

9. Zhou Y, Zhang X, Chen L, Wu J, Dang H, Wei M, Fan Y, Zhang Y, Zhu Y, Wang N, Breyer MD, Guan Y. (2008) Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats. Am J Physiol Renal Physiol. 295:F662-71

10. Ai D, Fu Y, Guo DL, Tanaka H, Wang N, Tang CS, Hammock BD, Shyy JY-J, Zhu Y*. (2007) Angiotensin II Upregulates Soluble Epoxide Hydrolase in Vascular Endothelium In vitro and In vivo. Proc Natl Acad Sci USA. 104:9018-9023.

11. Xie, XF, Zhu, Y * (2007) Insights into Cholesterol Efflux in Vascular Endothelial Cells. Cardiovascular Hematology Disorders - Drug Targets 7:127-134. (Invited Review)

12. Chen, M., Li, W., Wang, N., Zhu, Y. *, Wang, X.* (2007) ROS and NF-kB but not LXR mediate IL-1b signaling for the downregulation of ATP-binding cassette transporter A1. Am J Physiol Cell Physiol. 292:C1493-501

13. Wang T., Chen Z., Wang X., Shyy J. Y-J., Zhu Y*. (2006) Cholesterol Loading Increases the Translocation of ATP Synthase β Chain into Membrane Caveolae in Vascular Endothelial Cells. BBA – Mol Cell Biol L 1761:1182-1190

14. Dai, J., Li, W., Chang, L., Zhang Z., Tang, C. Wang, N., Zhu, Y., Wang, X. (2006) Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis. Free Radical Biol Med 41:1566-1577

15. Sun, W., Lee, T-S., Zhu, M.J., Gu, C., Wang, Y., Zhu, Y., Shyy, J Y-J. (2006) Statins Activate AMP-Activated Kinase in vitro and in vivo. Circulation 114:2655-2662

16. Liu Y, Zhang Y, Schmelzer K, Lee TS, Fang X, Zhu Y, Spector AA, Gill S, Morisseau C, Hammock BD, Shyy J. Y-J. (2005) The antiinflammatory effect of laminar flow: The role of PPAR{gamma}, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci USA 102:16747-52

17. Zhu Y,* Liao HL, Xie XF, Yuan Y, Lee TS, Wang N, Wang X, Shyy JY, Stemerman MB. (2005) Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting LXR. Cardiovas Res68:425-432.

18. Zeng L, Liao HL, Liu Y, Lee TS, Zhu MJ, Wang X, Stemerman MB, Zhu Y,* Shyy JY. (2004) SREBP2 downregulates ABCA1: a novel role of SREBP in regulating cholesterol metabolism.J Biol Chem 279:48801-7.

19. Liu, Y., Zhu, Y., Rannou, F., Lee, T-S., Formentin, K., Zeng, L., Yuan, X., Wang, N., Chien, S., Forman, B.M., Shyy, J. Y-J. (2004) Laminar Flow Activates Peroxisome Proliferator-Activator Receptor g in Vascular Endothelial Cells. Circulation 110:1128-1133.

20. Lee, T-S., Chih-Chieh Chang, C.C., Zhu, Y., Shyy J. Y-J. (2004) Simvastatin Induces Heme Oxygenase-1: A Novel Mechanism of Vessel Protection. Circulation 110:1296-1302.

21. Zhou, R.H., Yao, M., Lee, T-S., Zhu, Y., Martins-Green, M., Shyy J. Y-J. (2004) VEGF Activation of SREBP: A Potential Role in Angiogenesis. Circ Res. 95:471-478.

22. Zhu, Y.,* Liao, H.L., Yuan, Y., Verna, L., Stemerman, M.B. (2003) Low density lipoprotein induces eNOS translocation to membrane caveolae via stress fibers. BBA – Mol Cell Biol L 1635:117-126.

23. Liao, H.L., Langmann, T., Schmitz, G., Zhu, Y.* (2002) Native LDL transcriptionaly upregulates ATP-binding cassette transporter-1 in human vascular endothelial cells. Arterio Thromb Vasc Biol 22:127-132

24. Zhu, Y.,* Liao, HL., Wang, N., Ma, K-S., Verna, L., Shyy, J.Y-J., Chien, S., Stemerman, M.B. (2001) Low-density lipoprotein-activated p38 in endothelial cells is mediated by Ras. Arterio Thromb Vasc Biol 21:1159-1164

25. Liao, HL., Zhu, Y.,* Wang, N., Verna, L., Stemerman, M.B. (2000) Selective activation of endothelial cells by the antioxidant pyrrolidine dithiocarbamate: involvement of c-Jun and Jun N-terminal kinase activation. Endothelium 7:121-133

26. Zhu, Y.,* Liao, HL., Wang, N., Yuan,Y., Ma, K-S., Verna, L., Stemerman, M.B. (2000) Lipoprotein promotes caveolin-1 and Ras translocation to caveolae: role of cholesterol in endothelial signaling. Arterio Thromb Vasc Biol 20:2465-2470

27. Zhu, Y.,* Liao, HL., Wang, N., Friedli, O., Verna, L., Stemerman, M.B. (1999) Low-Density Lipoprotein Activates Jun N-terminal Kinase (JNK) in Human Endothelial Cells. BBA – Mol Cell Biol L 1436:557-564

28. Zhu, Y.,* Liao, HL., Lin, J.H-C, Verna, L., Stemerman, M.B. (1999) Low-density lipoprotein Augments Interleukin-1-induced Vascular Adhesion Molecule expression in Human Endothelial Cells. Atherosclerosis 144:357-365.

29. Zhu, Y.,* Lin, J.H-C., Liao, HL., Friedli, O., Verna, L., Marten, N.W., Straus, D.S., Stemerman, M.B. (1998) Low-density lipoprotein induces transcription factor activator protein-1(AP-1) in human endothelial cells. Arterio Thromb Vasc Biol 18: 473-480.

30. Zhu, Y.,* Lin, J.H-C., Liao, HL., Verna, L., Stemerman, M.B. (1997) Activation of ICAM-1 promoter by lysophosphatidylcholine: possible involvement of protein tyrosine kinases. Biochem Biophys Acta 1345:93-98.

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