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汪南平 教授 实验室主任
北京大学心血管研究所 副所长
北京大学糖尿病中心 副主任
Nanping Wang
Professor and associate director,
Institute of Cardiovascular Sciences and Diabetes Center,
Peking University,
Phone：010-82801146
Fax： 010-82802769
E-mail：npwang@bjmu.edu.cn
教育经历
Education
1994 Ph.D, 北京医科大学 (Beijing Medical University)
工作经历
Professional experience
2003-present 北京大学医学部心血管研究所教授
2000-2003 美国加利福尼亚大学研究助理教授
1996-2000 美国加利福尼亚大学博士后
1995-1996 美国印第安娜大学博士后
1994-1995 德国柏林自由大学Benjamin Franklin医学中心客座研究员
1989-1990 日本北里大学医学部访问学者
1986-1991 西安医科大学第二附属医院医师
学术兼职
Academic activities
中国生理学会学术委员会副主任委员
中国病理生理学会受体与信号转导专业委员会委员
Circulation J 国际副主编
PPAR Research 副主编
J Diabetes 编委
主要在研科研基金 (Research fundings)：
国家自然科学基金 (30670848)：Krűppel-样因子4在血管内皮机械生物信号传导中的作用-课题负责人
科技部重大基础研究973项目课题 (2006503906):血管病变与二型糖尿病发病机制-课题负责人
国家自然科学基金委重大项目(30890040)：代谢性核受体与糖脂代谢-项目负责人
国家自然科学基金委创新群体项目 (30821001)：代谢综合症及其血管病变-课题负责人
北京大学医学部-工学院联合研究基金：以血管新生为靶点的小分子调节microRNA的研究-课题负责人
科技部重大基础研究973项目课题：细胞膜重要脂质代谢产物对重大疾病病理生理过程的调控 –课题骨干
研究室成员
staff
张 弘 副研究员
秦晓梅 副研究员
赵蓓蕾 技师
郝广华 博士后
王晓红 研究生07级
夏 龙 研究生07级
黄雅姿 研究生08级
胡方精 研究生08级
刘雅涵 研究生03级（8年制基础医学）
刘伟伟 研究生08级
方 希 研究生09级
李 娜 研究生09级
李津津 研究生09级
研究室概述 Research description
本研究室采用分子生物学、功能基因组学方法通过培养细胞和整体动物模型探讨代谢相关的血管疾病的发病机制，以期寻找其治疗的新靶点。主要研究方向包括：
1）动脉粥样硬化及血管再狭窄分子病理机制和治疗靶点：主要研究生长因子、脂肪因子对血管内皮细胞、平滑肌细胞增殖与迁移及血管损伤后新生内膜形成的影响；
2）血管机械-生物信号传导机制：主要集中研究血流机械剪应力调节血管内皮细胞基因表达的信号通路和转录机制；
3）代谢性核受体对糖脂代谢的调控机制：主要研究PPARa、d、g糖脂代谢相关靶基因的调控机制及其在脂肪合成和血管内皮细胞功能调节中的作用
研究论文 (Selected Publication)
1. Wang, N., Verna, L., Hardy, S., Forsayeth, J., Zhu, Y., Ma, K.S., Stemerman, M.B. Adenovirus-mediated Overexpression of c-Jun and c-Fos Induces Intercellular Adhesion Molecule-1 and Monocyte Chemo-attractant Protein-1 in Human Endothelial Cells. Arterioscler Thromb Vasc Biol. 1999; 19:2078-2084
2. Wang, N., Verna, L., Hardy, S., Ma, K., Zhu, Y., Birrer, MJ., Stemerman, M.B. c-Jun Triggers Apoptosis in Human Vascular Endothelial Cells. Circ Res. 1999; 85: 387-393
3. Wang, N., Verna, L., Zhu, Y., Liao, H., Ballard, A., Stemerman, MB. Adenovirus-mediated Overexpression of A Dominant Negative Mutant of c-Jun Prevents Intercellular Adhesion Molecule-1 Induction by LDL-A Critical Role for AP-1 in Endothelial Activation. Arterioscler Thromb Vasc Biol. 2001; 21: 1414-1420
4. Wang, N., Stemerman, MB. Ref-1 and Transcriptional Control of Endothelial Apoptosis. Circ Res 2001; 88:1223 –1225
5. Wang, N., Verna, L., Chen, N., Chen,J., Li, H, Forman, B.M., Stemerman, MB. Constitutive Activation of PPAR-gamma Suppresses Expression of Adhesion Molecules in Vascular Endothelial Cells. J Biol Chem 2002; 277: 34176-34181
6. Liu,Y., Zhu, Y., Rannou, F., Formentin, K., Zeng, L-F., Yuan X, BM. Forman, Wang N., Chien, S., Shyy J. Y-J. Shear Stress Increases the Endothelial Release of Ligands for Peroxisome Proliferator-Activated Receptor-gamma. Circulation2004 110:1128-33
7. Zhu, Y.,Liao, H., Xie, XF., Yuan, Y., Lee, T-S., Wang, N., Wang, X., Shyy, J.Y-J., Stemerman, MB.Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting LXR. Cardiovas Res 2005；68:425-432.
8. Wang,N.; Miao,H.; Li,Y.S.; Zhang,P.; Haga,J.H.; Hu,Y.; Young,A.; Yuan,S.; Nguyen,P.; Wu,C.C.; Chien,S. Shear stress regulation of Kruppel-like factor 2 expression is flow pattern-specific. Biochem Biophys Res Commun. 2006; 341:1244-1251
9. Li J, Wang N.Peroxisome proliferator-activated receptor-gamma in vascular biology. Cardiovasc Hematol Disord Drug Targets. 2007;7:109-17.
10. Gao DF, Niu XL, Hao GH, Peng N, Wei J, Ning N, Wang N. Rosiglitazone inhibits angiotensin II-induced CTGF expression in vascular smooth muscle cells-Role of PPAR-gamma in vascular fibrosis. Biochem Pharmacol. 2007, 73:185-97
11. Qin X, Tian J, Zhang P, Fan Y, Chen L, Guan Y, Fu Y, Zhu Y, Chien S, Wang N. Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells. Cardiovasc Res. 2007; 74:506-14.
12. Dwarakanath RS, Sahar S, Lanting L, Wang N, Stemerman MB, Batarajan R, Reddy MA. Viral Vector Mediated 12/15-Lipoxygenase Overexpression in Vascular Smooth Muscle Cells Enhances Inflammatory Gene Expression and Migration. J Vasc Res. 2007; 45:132-142
13. Ai D, Fu Y, Guo DL, Tanaka H, Wang N, Tang CS, Hammock BD, Shyy JY-J, Zhu Y. Angiotensin II Upregulates Soluble Epoxide Hydrolase in Vascular Endothelium In vitro and In vivo. Proc Natl Acad Sci USA. 2007; 104:9018-9023
14. Zhu M, Fu Y, Wang N, Guan Y, Tang CS, Shyy J.Y-J., Zhu Y. Laminar Shear Stress Regulates Liver X Receptor in Vascular Endothelial Cells In vitro and In vivo. Arterio Thromb Vasc Biol. 2008;28:527-33
15. Fan Y, Wang Y, Zhang H, Qin X, Zhu Y, Guan Y, Wang X, Staels B, Chien S, Wang N.Suppression of Pro-inflammatory Adhesion Molecules by PPAR-d in Human Vascular Endothelial Cells. Arterioscler Thromb Vasc Biol. 2008;28:315-2
16. Hao, G, Niu, X, Gao, D, Wei J, Wang N. PPAR-g ligands suppress angiotensin II-induced plasminogen activator inhibitor-1 and extracellular matrix production in rat cardiac fibroblasts. British J Pharmacol, 2008;153:1409-1419.
17. Qin X, Xue XF, Fan Y, Tian J, Guan Y, Wang X, Zhu Y, Wang N. Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice. Hepatology.2008; 48:432-41
18. Zhang H, Li Y, Fan Y, Wu J, Zhao B, Guan Y, Chien S, Wang N. Klotho is a target gene of PPAR-gamma. Kidney International 2008; 74:732-9
19. Tang Z, Wang Y, Fan Y, Zhu Y, Chien S and Wang N. Suppression of c-Cbl Tyrosine Phosphorylation Inhibits Proliferation and Migration of Vascular Smooth Muscle Cells in vitro and Neointima Formation in Balloon-Injured Rat Arteries. Circulation. 2008; 118:764-72.
20. Li Y, Jiang C, Xu G, Wang N, Zhu Y, Tang C, Wang X. Homocysteine upregulates resistin production from adipocytes in vivo and in vitro. Diabetes. 2008;57:817-27
21. Wang N. PPAR-d in Vascular Pathophysiology. PPAR Res. Epub 2008; Dec
22. Zhou Y; Zhang X; Chen L; Wu J; Dang H; Wei M; Fan Y; Zhang Y; Zhu Y; Wang N, Breyer M, Guan Y. Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats. Am J Physiol Renal Physiol.2008; 295:F662-71
23. Zhang P, Wang Y, Fan Y, Tang Z, Wang N. Overexpression of Adiponectin Receptors Potentiates the Anti-inflammatory Action of Subeffective Dose of Globular Adiponectin in Vascular Endothelial Cells. Arterioscler Thromb Vasc Biol. 2009; 29:67-74
24. Dang H, Pang W, Liu Y, Wang N, Shyy JY-J, Zhu Y. Suppression of 2,3-Oxidosqualene Cyclase by High-Fat Diet Contributes to Liver X Receptor-a-mediated Improvement of Hepatic Lipid Profile. J Biol Chem. 2009; 284:6218-26
25. Wang L, Zheng J, Bai X, Liu B, Liu CJ, Xu Q, Zhu Y, Wang N, Kong W, Wang X. ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-Injured Rat Arteries. Circ Res.2009; 104:688-98
26. Zhang P, Wang H, Min X, Wang Y, Tang J, Cheng J, Li D, Chen X, Cheng F, WangN, Yang H. Pim-3 is expressed in endothelial cells and promotes vascular tube formation. J Cell Physiol. 2009; 220:82-90.
27. Xu, G., Li, Y., An, W., Li, S., Guan, Y., Wang, N., Tang, C., Wang, X., Zhu, Y., Li, X., Mulholland, M. W., and Zhang, W. Gastric mTOR signaling regulates ghrelin production and food intake. Endocrinology, 2009;150:3637-44
28. Chen L, Yang G, Zhang X, Wu J, Gu Q, Wei M, Zhu Y, Wang N, Guan Y. Induction of MIF expression by oxidized LDL via activation of NF-κB in vascular smooth muscle cells. Atherosclerosis, 2009; May 27. [Epub ahead of print]
29. Tsai M-C, Chen L, Zhou J, Tang Z, Hsu T-F, Wang Y, Shih Y-T, Peng H-H, Wang N, Guan Y, Chien S, Chiu J-J. Shear Stress Induces Synthetic-to-Contractile Phenotypic Modulation in Smooth Muscle Cells via PPAR-a/d Activations by Prostacyclin Released by Sheared Endothelial Cells. Circ Res, 2009; Jul 23. [Epub ahead of print]
30. Young A, Wu W, Sun W, Larman H, Wang N, Li Y-S, Shyy J-Y, Chien S, Garcia-Cardena G. Flow-mediated Activation of AMP-activated Protein Kinase Regulates Krüppel-like factor 2 Expression in Vascular Endothelial Cells. Arterioscler Thromb Vasc Biol 2009; Aug 20. [Epub ahead of print] |
