主任

 教育经历

Education

1984         白求恩医科大学医学系   医学学士

              Department of Medicine, Norman Bethune University of Medical Sciences, Changchun, China, M.D.

1987         白求恩医科大学医学遗传学教研室   医学遗传学硕士

              Department of Medical Genetics, Norman Bethune University of Medical Sciences, Changchun, China, M.S.

1993         白求恩医科大学免疫学教研室   免疫学博士

              Department of Immunology, Norman Bethune University of Medical Sciences, Changchun, China, Ph.D. 

 

2007-present    北京大学基础医学院药理学系 教授, 博士生导师, 系副主任

                                 Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

2003-2009               美国加州大学旧金山分校医学系, 助理教授

                                 Assistant professor, Department of medicine, University of California, San Francisco, USA

1997-2003       美国加州大学旧金山分校医学系, 助理研究员

                                 Assistant Molecular Biologist, Department of medicine, University of California, San Francisco, USA

1994-1997       美国加州大学旧金山分校心血管研究所 博士后

                Postdoctoral Fellow, Cardiovascular Research Institute, University of California, San Francisco, USA

1993-1994       白求恩医科大学免疫学教研室 副教授

                Associate Professor, Department of Immunology,Norman Bethune University of Medical Sciences, Changchun, China

1997-2000       白求恩医科大学医学遗传学教研室 讲师  

                Lecturer, Department of Medical Genetics, Norman Bethune University of Medical Sciences, Changchun, China

 

研究室成员：

周虹 讲师

雷天落 讲师

高晋生 博士生 07级

李欣 博士生 08 级

李飞 博士生 09 级

周澧 博士生 04 级 (八年制)

陈霁辉 博士生 05 级 (八年制)

孙颖 博士生 06 级 (八年制)

 

研究室概述：

本研究室致力于心血管疾病相关药物新靶点探索、新型利尿剂研发、膜通道蛋白生理学与药理学研究、多囊肾发病机制和治疗研究。目前已建立多囊肾药物开发研究平台、水通道和尿素通道抑制剂筛选平台和膜通道蛋白生理学与药理学研究平台。具有良好的分子生物学、生理学和药理学研究条件。拥有多囊肾小鼠模型、水通道蛋白基因敲除小鼠模型和尿素通道蛋白基因敲除小鼠模型。已与美国Verkman 研究小组、美国Sands研究小组、法国Bankir研究小组和吉林大学病理生理学教研室进行合作研究。本实验室并不局限于已建立的研究框架，愿意同其他研究单位开展联合研究项目。

 

Research Description:

The main interest of the laboratory is focused on drug targets on cardiovascular diseases, new diuretics discovery, physiology and pharmacology of membrane channel proteins, and mechanism and therapy of polycystic kidney disease. The platforms for studying polycystic kidney disease, screening inhibitors of aquaporins and urea transporters and investigating physiology and pharmacology of membrane channel proteins have been established. There is good research condition for the research work on molecular biology, physiology and pharmacology. We have polycystic kidney disease mouse model, aquaporin gene knockout mouse models and urea transporter gene knockout mouse models. We collaborate with Verkman’s group (UCSF, USA), Sands’ group (Emory University, USA), Bankir’s group (Inserm, France) and Department of Pathophysiology, Jilin University on several joint projects. We would like to have collaboration with the other groups for joint projects in various research fields.

 

Selected Publications: